Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
---- 7.11 7.11 5.40 7.11 5.40
---+ 7.11 7.11 5.40 7.11 17.01
--+- 7.11 7.11 5.40 7.11 5.40
--++ 7.11 7.11 5.40 7.11 17.01
-+-- 7.11 7.11 17.01 7.11 5.40
-+-+ 7.11 7.11 17.01 7.11 17.01
-++- 7.11 7.11 17.01 7.11 5.40
-+++ 7.11 7.11 17.01 7.11 17.01
+--- 7.11 7.11 5.40 7.11 5.40
+--+ 7.11 7.11 5.40 7.11 17.01
+-+- 7.11 7.11 5.40 7.11 5.40
+-++ 7.11 7.11 5.40 7.11 17.01
++-- 7.11 7.11 17.01 7.11 5.40
++-+ 7.11 7.11 17.01 7.11 17.01
+++- 7.11 7.11 17.01 7.11 5.40
$superiority
Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
all 0 0 0 0 0
TP53- & AR- 0 0 0 0 0
TP53+ 0 0 0 0 0
DRD+ 0 0 1 0 0
TEfus+ 0 0 0 0 1
$inferiority
Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
all 0 0 0 0 0
TP53- & AR- 0 0 0 0 0
TP53+ 0 0 0 0 0
DRD+ 0 0 0 0 0
TEfus+ 0 1 0 0 0
$p_sign
Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
all 0.03 0.02 0.23 0.01 0.19
TP53- & AR- 0.38 0.12 0.98 0.35 0.36
TP53+ 0.10 0.18 0.07 0.07 0.34
DRD+ 0.11 0.09 0.80 0.06 0.08
TEfus+ 0.01 0.00 0.04 0.00 0.48
$p_type
Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
---- 0.06 0.29 0.08 0.42 0.13
---+ 0.34 0.07 0.29 0.16 0.64
--+- 0.78 0.91 0.33 0.89 0.74
--++ 0.20 0.14 0.09 0.16 0.82
-+-- 0.78 0.71 1.00 0.75 0.32
-+-+ 0.52 0.19 0.84 0.50 0.38
-++- 0.78 0.73 0.76 0.62 0.62
-+++ 0.08 0.15 0.18 0.18 0.17
+--- 0.50 0.29 0.20 0.34 0.13
+--+ 0.26 0.18 0.20 0.31 0.77
+-+- 0.46 0.50 0.44 0.38 0.38
+-++ 0.02 0.05 0.01 0.03 0.36
++-- 0.08 0.09 0.44 0.06 0.07
++-+ 0.15 0.15 0.20 0.10 0.40
+++- 0.42 0.48 0.38 0.32 0.32
Control Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
---- 87 52 80 18 79 31
---+ 17 20 8 4 12 6
--+- 43 38 42 22 32 32
--++ 51 13 8 15 18 7
-+-- 17 13 13 12 12 8
-+-+ 22 10 2 4 10 0
-++- 4 1 0 1 5 3
-+++ 3 1 2 1 3 0
+--- 10 6 5 4 10 7
+--+ 12 10 2 3 12 3
+-+- 4 2 2 0 2 1
+-++ 21 5 2 4 5 3
++-- 9 11 4 1 7 2
++-+ 5 2 1 0 3 1
+++- 2 2 2 1 5 5
Control Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
all 307 186 173 90 215 109
TP53- & AR- 143 95 103 38 113 45
TP53+ 128 62 58 44 70 51
DRD+ 62 40 24 20 45 19
TEfus+ 131 61 25 31 63 20
Sample of 10 rows:
id trt trt2 line subtype delta month0 time_m all TP53- & AR- TP53+ DRD+ TEfus+
448 411 Carboplatin Carboplatin 1 --+- 1 13 3.2212011 1 0 1 0 0
139 130 Enzalutamide Enzalutamide 1 ---- 1 4 2.6587299 1 1 0 0 0
266 249 Enzalutamide Enzalutamide 1 --+- 1 8 5.4700406 1 0 1 0 0
769 692 Control Enzalutamide 1 ---- 1 23 1.2719507 1 1 0 0 0
166 155 Control Abiraterone 1 -+-- 1 5 6.6289854 1 1 0 1 0
286 269 Docetaxel Docetaxel 1 +-+- 1 8 0.6937390 1 0 1 0 0
588 531 Cabazitaxel Cabazitaxel 1 ---- 1 17 8.0275362 1 1 0 0 0
1079 966 Control Docetaxel 1 +-++ 0 32 4.0000000 1 0 1 0 1
503 452 Control Enzalutamide 1 ---- 1 15 3.5181482 1 1 0 0 0
648 584 Enzalutamide Enzalutamide 1 -+-- 1 19 0.8915835 1 1 0 1 0
Mean number of progressions and follow-up time:
$all
# A tibble: 6 x 4
trt progressions PT rate
<fct> <dbl> <dbl> <dbl>
1 Control 261 2213. 0.118
2 Enzalutamide 166 1101. 0.151
3 Abiraterone 157 1049. 0.150
4 Carboplatin 86 689. 0.125
5 Cabazitaxel 200 1395. 0.143
6 Docetaxel 104 785. 0.132
$`TP53- & AR-`
# A tibble: 6 x 4
trt progressions PT rate
<fct> <dbl> <dbl> <dbl>
1 Control 129 1015. 0.127
2 Enzalutamide 89 606. 0.147
3 Abiraterone 96 638. 0.150
4 Carboplatin 36 442. 0.0814
5 Cabazitaxel 101 760. 0.133
6 Docetaxel 43 274. 0.157
$`TP53+`
# A tibble: 6 x 4
trt progressions PT rate
<fct> <dbl> <dbl> <dbl>
1 Control 107 864. 0.124
2 Enzalutamide 55 332. 0.166
3 Abiraterone 50 355. 0.141
4 Carboplatin 43 186. 0.231
5 Cabazitaxel 69 432. 0.160
6 Docetaxel 47 373. 0.126
$`DRD+`
# A tibble: 6 x 4
trt progressions PT rate
<fct> <dbl> <dbl> <dbl>
1 Control 50 465. 0.108
2 Enzalutamide 39 278. 0.140
3 Abiraterone 26 153. 0.170
4 Carboplatin 17 381. 0.0446
5 Cabazitaxel 46 288. 0.160
6 Docetaxel 21 93.4 0.225
$`TEfus+`
# A tibble: 6 x 4
trt progressions PT rate
<fct> <dbl> <dbl> <dbl>
1 Control 99 1014. 0.0976
2 Enzalutamide 53 350. 0.152
3 Abiraterone 27 94.1 0.287
4 Carboplatin 30 194. 0.155
5 Cabazitaxel 57 361. 0.158
6 Docetaxel 20 332. 0.0602
Kaplan-Meier results:
$all
Call: survfit(formula = Surv(time_m, delta) ~ trt, data = d)
n events median 0.95LCL 0.95UCL
trt=Control 343 261 5.72 4.83 6.68
trt=Enzalutamide 203 166 4.46 3.72 5.50
trt=Abiraterone 193 157 4.46 3.78 5.49
trt=Carboplatin 100 86 4.36 3.68 6.36
trt=Cabazitaxel 247 200 5.02 4.24 5.74
trt=Docetaxel 126 104 4.82 3.61 7.99
$`TP53- & AR-`
Call: survfit(formula = Surv(time_m, delta) ~ trt, data = d)
n events median 0.95LCL 0.95UCL
trt=Control 161 129 5.22 4.19 7.00
trt=Enzalutamide 103 89 4.12 3.17 6.05
trt=Abiraterone 114 96 4.44 3.56 5.49
trt=Carboplatin 43 36 9.23 3.96 15.60
trt=Cabazitaxel 133 101 5.02 3.97 5.82
trt=Docetaxel 53 43 4.79 3.57 8.42
$`TP53+`
Call: survfit(formula = Surv(time_m, delta) ~ trt, data = d)
n events median 0.95LCL 0.95UCL
trt=Control 145 107 5.44 4.54 6.68
trt=Enzalutamide 70 55 4.63 3.66 6.27
trt=Abiraterone 66 50 5.57 3.69 7.88
trt=Carboplatin 47 43 3.77 2.84 5.49
trt=Cabazitaxel 79 69 4.91 3.74 6.59
trt=Docetaxel 57 47 6.00 3.34 9.18
$`DRD+`
Call: survfit(formula = Surv(time_m, delta) ~ trt, data = d)
n events median 0.95LCL 0.95UCL
trt=Control 69 50 5.62 4.01 9.72
trt=Enzalutamide 47 39 4.12 2.64 7.48
trt=Abiraterone 30 26 3.36 2.47 7.33
trt=Carboplatin 20 17 18.70 12.26 31.80
trt=Cabazitaxel 52 46 4.90 3.85 6.88
trt=Docetaxel 22 21 2.79 1.89 6.29
$`TEfus+`
Call: survfit(formula = Surv(time_m, delta) ~ trt, data = d)
n events median 0.95LCL 0.95UCL
trt=Control 145 99 7.00 5.62 9.36
trt=Enzalutamide 68 53 4.64 2.64 6.26
trt=Abiraterone 27 27 2.53 1.80 4.46
trt=Carboplatin 35 30 4.36 3.04 7.86
trt=Cabazitaxel 69 57 4.82 3.89 7.88
trt=Docetaxel 22 20 12.55 12.00 21.18